Article
Error baseline rates of five sample preparation methods used to characterize RNA virus populations.
PloS one - 1 Jan 2017
Kugelman Jeffrey R, Wiley Michael R, Nagle Elyse R, Reyes Daniel, Pfeffer Brad P, Kuhn Jens H, Sanchez-Lockhart Mariano, Palacios Gustavo F
Abstract excerpt
Individual RNA viruses typically occur as populations of genomes that differ slightly from each other due to mutations introduced by the error-prone viral polymerase. Understanding the variability of RNA virus genome populations is critical for understanding virus evolution because individual mutant genomes may gain evolutionary selective advantages and give rise to dominant subpopulations, possibly even leading...
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