Article
Optimized quantification of intra-host viral diversity in SARS-CoV-2 and influenza virus sequence data.
mBio - 31 Aug 2023
Roder A E, Johnson K E E, Knoll M, Khalfan M, Wang B, Schultz-Cherry S, Banakis S, Kreitman A, Mederos C, Youn J-H, Mercado R, Wang W, Chung M, Ruchnewitz D, Samanovic M I, Mulligan M J, Lässig M, Luksza M, Das S, Gresham D, Ghedin E
Abstract excerpt
High error rates of viral RNA-dependent RNA polymerases lead to diverse intra-host viral populations during infection. Errors made during replication that are not strongly deleterious to the virus can lead to the generation of minority variants. However, accurate detection of minority variants in viral sequence data is complicated by errors introduced during sample preparation and data analysis. We used synthetic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.