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Article

Pilot study of CYP2B6 genetic variation to explore the contribution of nitrosamine activation to lung carcinogenesis.

International journal of molecular sciences - 16 Apr 2013

Wassenaar Catherine A, Dong Qiong, Amos Christopher I, Spitz Margaret R, Tyndale Rachel F

Abstract excerpt

We explored the contribution of nitrosamine metabolism to lung cancer in a pilot investigation of genetic variation in CYP2B6, a high-affinity enzymatic activator of tobacco-specific nitrosamines with a negligible role in nicotine metabolism. Previously we found that variation in CYP2A6 and CHRNA5-CHRNA3-CHRNB4 combined to increase lung cancer risk in a case-control study in European American ever-smokers (n =...

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Source

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Identifiers

PMID: 23591849
DOI: 10.3390/ijms14048381
PMCID: PMC3645749

Genes

CHRNA3
CHRNA5
CHRNB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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