Article
Association between CYP2A6 genetic polymorphisms and lung cancer: a meta-analysis of case-control studies.
Environmental and molecular mutagenesis - 1 Mar 2013
Liu Tao, Xie Chuan-Bo, Ma Wen-Jun, Chen Wei-Qing
Abstract excerpt
Cytochrome P450 2A6 (CYP2A6) is an enzyme responsible for the metabolism of nicotine and some tobacco-specific carcinogens (such as N-nitrosamines). CYP2A6 genetic variations are associated with the activity of the CYP2A6 enzyme, which affects smoking behavior and the rate at which some tobacco-specific carcinogens are metabolized, which in turn determines the incidence of lung cancer. Several studies have...
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