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Article

Not5-dependent co-translational assembly of Ada2 and Spt20 is essential for functional integrity of SAGA.

Nucleic acids research - 17 Feb 2017

Kassem Sari, Villanyi Zoltan, Collart Martine A

Abstract excerpt

Acetylation of histones regulates gene expression in eukaryotes. In the yeast Saccharomyces cerevisiae it depends mainly upon the ADA and SAGA histone acetyltransferase complexes for which Gcn5 is the catalytic subunit. Previous screens have determined that global acetylation is reduced in cells lacking subunits of the Ccr4–Not complex, a global regulator of eukaryotic gene expression. In this study we have...

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Identifiers

PMID: 28180299
DOI: 10.1093/nar/gkw1059
PMCID: PMC5388395

Genes

ADA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Not5-dependent co-translational assembly of Ada2 and Spt20 is essential for functional integrity of SAGA.PMID 28180299Read ↗

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