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Article

Conformational flexibility and subunit arrangement of the modular yeast Spt-Ada-Gcn5 acetyltransferase complex.

The Journal of biological chemistry - 17 Apr 2015

Setiaputra Dheva, Ross James D, Lu Shan, Cheng Derrick T, Dong Meng-Qiu, Yip Calvin K

Abstract excerpt

The Spt-Ada-Gcn5 acetyltransferase (SAGA) complex is a highly conserved, 19-subunit histone acetyltransferase complex that activates transcription through acetylation and deubiquitination of nucleosomal histones in Saccharomyces cerevisiae. Because SAGA has been shown to display conformational variability, we applied gradient fixation to stabilize purified SAGA and systematically analyzed this flexibility using...

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Identifiers

PMID: 25713136
DOI: 10.1074/jbc.M114.624684
PMCID: PMC4400322

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