Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes.

Molecular systems biology - 5 Jul 2011

Lee Kenneth K, Sardiu Mihaela E, Swanson Selene K, Gilmore Joshua M, Torok Michael, Grant Patrick A, Florens Laurence, Workman Jerry L, Washburn Michael P

Abstract excerpt

Despite the availability of several large-scale proteomics studies aiming to identify protein interactions on a global scale, little is known about how proteins interact and are organized within macromolecular complexes. Here, we describe a technique that consists of a combination of biochemistry approaches, quantitative proteomics and computational methods using wild-type and deletion strains to investigate the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin Assembly and Disassembly
Share to Computational Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Databases, Genetic

Share to Gene Deletion

Share to Histone Acetyltransferases

Share to Proteomics

Share to Saccharomyces cerevisiae Proteins

Share to Trans-Activators

Source

Open in PubMed Open full text

Identifiers

PMID: 21734642
DOI: 10.1038/msb.2011.40
PMCID: PMC3159981

Genes

ADA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes.PMID 21734642Read ↗

The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae.Semantic proximity Read ↗

Functional organization of the yeast SAGA complex: distinct components involved in structural integrity, nucleosome acetylation, and TATA-binding protein interaction.Semantic proximity Read ↗

Conformational flexibility and subunit arrangement of the modular yeast Spt-Ada-Gcn5 acetyltransferase complex.Semantic proximity Read ↗

The SANT domain of Ada2 is required for normal acetylation of histones by the yeast SAGA complex.Semantic proximity Read ↗

TFIID and Spt-Ada-Gcn5-acetyltransferase functions probed by genome-wide synthetic genetic array analysis using a Saccharomyces cerevisiae taf9-ts allele.Semantic proximity Read ↗

Function and regulation of the Spt-Ada-Gcn5-Acetyltransferase (SAGA) deubiquitinase module.Semantic proximity Read ↗

The Transcriptional Coactivator ADA2b Recruits a Structural Maintenance Protein to Double-Strand Breaks during DNA Repair in Plants.Semantic proximity Read ↗

Not5-dependent co-translational assembly of Ada2 and Spt20 is essential for functional integrity of SAGA.Semantic proximity Read ↗

Multi-tasking on chromatin with the SAGA coactivator complexes.Semantic proximity Read ↗

Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo.Semantic proximity Read ↗

Uncovering the role of Sgf73 in maintaining SAGA deubiquitinating module structure and activity.Semantic proximity Read ↗

Essential functional interactions of SAGA, a Saccharomyces cerevisiae complex of Spt, Ada, and Gcn5 proteins, with the Snf/Swi and Srb/mediator complexes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.