Article
Single Mutations Reshape the Structural Correlation Network of the DMXAA-Human STING Complex.
The journal of physical chemistry. B - 9 Mar 2017
Che Xing, Du Xiao-Xia, Cai Xiaoxia, Zhang Jun, Xie Wen Jun, Long Zhuoran, Ye Zhao-Yang, Zhang Heng, Yang Lijiang, Su Xiao-Dong, Gao Yi Qin
Abstract excerpt
Subtle changes in protein sequences are able to alter ligand-protein interactions. Unraveling the mechanism of such phenomena is important for understanding ligand-protein interactions, including the DMXAA-STING interaction. DMXAA specifically binds to mouse STING instead of human STING. However, the S162A mutation and a newly discovered E260I mutation endow human STINGAQ with DMXAA sensitivity. Through molecular...
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