Article

The HAQ STING mutation interacts with COPA causing allosteric structural rearrangements in COPA that may protect against COPA disease

2025-03-11

Abstract excerpt

<h4>Background</h4> COPA disease is a rare autoinflammatory disorder caused by mutations in the COPA gene, leading to immune dysregulation and inflammatory pathology. The HAQ STING allele has been identified as a protective factor against disease manifestation. Understanding the molecular interaction between HAQ STING and COPA is critical for uncovering potential therapeutic strategies. <h4>Methods</h4> This stu...

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Literature Corpus work: e719e273-d235-58f8-b19c-d72815ea28a0
DOI: 10.1101/2025.03.07.642091

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