Article
Simultaneous in vivo phenotyping of CYP enzymes.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013
Ghassabian Sussan, Murray Michael
Abstract excerpt
As major determinants of the duration of drug action the CYP enzymes strongly influence drug efficacy and toxicity. In vivo phenotyping for CYP activities using cocktails of well-tolerated CYP-specific substrates may be valuable in the development of personalized medicine protocols, particularly for drugs that have significant toxicity profiles. However, the use of the cocktail approach in the clinic is dependent...
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