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Article

"Cocktail" approaches and strategies in drug development: valuable tool or flawed science?

Journal of clinical pharmacology - 1 Feb 2004

Zhou Honghui, Tong Zeen, McLeod James F

Abstract excerpt

There is an increasing interest in the simultaneous administration of several probe substrates to characterize the activity of multiple drug-metabolizing enzymes, the so-called "cocktail" approach. However, this method remains controversial and is being investigated more extensively. No general consensus has emerged on the applicability of this approach in clinical investigation and during drug development. The...

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Identifiers

PMID: 14747420
DOI: 10.1177/0091270003261333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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