Safety of the Geneva Cocktail, a Cytochrome P450 and P-Glycoprotein Phenotyping Cocktail, in Healthy Volunteers from Three Different Geographic Origins.

doi:10.1007/s40264-020-00983-8

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Safety of the Geneva Cocktail, a Cytochrome P450 and P-Glycoprotein Phenotyping Cocktail, in Healthy Volunteers from Three Different Geographic Origins.

Drug safety - 1 Nov 2020

Rollason Victoria, Mouterde Médéric, Daali Youssef, Čížková Martina, Priehodová Edita, Kulichová Iva, Posová Helena, Petanová Jitka, Mulugeta Anwar, Makonnen Eyasu, Al-Habsi Abir, Davidson Robin, Al-Balushi Khalid K, Al-Thihli Khalid, Cerná Marie, Al-Yahyaee Said, Černý Viktor, Yimer Getnet, Poloni Estella S, Desmeules Jules

Abstract excerpt

INTRODUCTION AND OBJECTIVE: Cytochrome P450 enzymes are the major drug-metabolizing enzymes in humans and the importance of drug transport proteins, in particular P-glycoprotein, in the variability of drug response has also been highlighted. Activity of cytochrome P450 enzymes and P-glycoprotein can vary widely between individuals and genotyping and/or phenotyping can help assess their activity. Several...

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PMID: 32851583
DOI: 10.1007/s40264-020-00983-8
PMCID: PMC7575470

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