Article
Enhanced dependency of KRAS-mutant colorectal cancer cells on RAD51-dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae.
Molecular oncology - 1 May 2017
Kalimutho Murugan, Bain Amanda L, Mukherjee Bipasha, Nag Purba, Nanayakkara Devathri M, Harten Sarah K, Harris Janelle L, Subramanian Goutham N, Sinha Debottam, Shirasawa Senji, Srihari Sriganesh, Burma Sandeep, Khanna Kum Kum
Abstract excerpt
Activating KRAS mutations drive colorectal cancer tumorigenesis and influence response to anti-EGFR-targeted therapy. Despite recent advances in understanding Ras signaling biology and the revolution in therapies for melanoma using BRAF inhibitors, no targeted agents have been effective in KRAS-mutant cancers, mainly due to activation of compensatory pathways. Here, by leveraging the largest synthetic lethal...
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