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Article

Defects in homologous recombination repair in mismatch-repair-deficient tumour cell lines.

Human molecular genetics - 1 Sept 2002

Mohindra Atul, Hays Laura E, Phillips Eric N, Preston Bradley D, Helleday Thomas, Meuth Mark

Abstract excerpt

Loss of mismatch repair (MMR) leads to a complex mutator phenotype that appears to drive the development of a subset of colon cancers. Here we show that MMR-deficient tumour cell lines are highly sensitive to the toxic effects of thymidine relative to MMR-proficient lines. This sensitivity was not a direct consequence of MMR deficiency or alterations of DNA precursor metabolism. Instead, MMR-defective tumour cell...

Read the complete abstract on PubMed

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Share to Base Pair Mismatch
Share to Deoxyribonucleotides

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Repair

Share to Mitomycin

Share to Nucleic Acid Synthesis Inhibitors

Share to Recombination, Genetic

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Source

Identifiers

PMID: 12189171
DOI: 10.1093/hmg/11.18.2189

Genes

XRCC2
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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