Article
Fisetin overcomes non-targetability of mutated KRAS induced YB-1 signaling in colorectal cancer cells and improves radiosensitivity by blocking repair of radiation-induced DNA double-strand breaks.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Nov 2023
Khozooei Shayan, Veerappan Soundaram, Bonzheim Irina, Singer Stephan, Gani Cihan, Toulany Mahmoud
Abstract excerpt
BACKGROUND AND PURPOSE: KRAS is frequently mutated, and the Y-box binding protein 1 (YB-1) is overexpressed in colorectal cancer (CRC). Mutant KRAS (KRASmut) stimulates YB-1 through MAPK/RSK and PI3K/AKT, independent of epidermal growth factor receptor (EGFR). The p21-activated kinase (PAK) family is a switch-site upstream of AKT and RSK. The flavonoid compound fisetin inhibits RSK-mediated YB-1 signaling. We...
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