Article
The homologous recombination protein RAD51D protects the genome from large deletions.
Nucleic acids research - 28 Feb 2017
Reh Wade A, Nairn Rodney S, Lowery Megan P, Vasquez Karen M
Abstract excerpt
Homologous recombination (HR) is a DNA double-strand break (DSB) repair pathway that protects the genome from chromosomal instability. RAD51 mediator proteins (i.e. paralogs) are critical for efficient HR in mammalian cells. However, how HR-deficient cells process DSBs is not clear. Here, we utilized a loss-of-function HR-reporter substrate to simultaneously monitor HR-mediated gene conversion and...
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