Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oncogenic KRAS drives radioresistance through upregulation of NRF2-53BP1-mediated non-homologous end-joining repair.

Nucleic acids research - 8 Nov 2021

Yang Linlin, Shen Changxian, Estrada-Bernal Adriana, Robb Ryan, Chatterjee Moumita, Sebastian Nikhil, Webb Amy, Mo Xiaokui, Chen Wei, Krishnan Sunil, Williams Terence M

Abstract excerpt

KRAS-activating mutations are oncogenic drivers and are correlated with radioresistance of multiple cancers, including colorectal cancer, but the underlying precise molecular mechanisms remain elusive. Herein we model the radiosensitivity of isogenic HCT116 and SW48 colorectal cancer cell lines bearing wild-type or various mutant KRAS isoforms. We demonstrate that KRAS mutations indeed lead to radioresistance...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Breaks, Double-Stranded
Share to DNA End-Joining Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to G1 Phase Cell Cycle Checkpoints

Share to G2 Phase Cell Cycle Checkpoints

Share to Gamma Rays

Share to HCT116 Cells

Share to NF-E2-Related Factor 2

Share to Tumor Suppressor p53-Binding Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 34606602
DOI: 10.1093/nar/gkab871
PMCID: PMC8565339

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oncogenic KRAS drives radioresistance through upregulation of NRF2-53BP1-mediated non-homologous end-joining repair.PMID 34606602Read ↗

Fisetin overcomes non-targetability of mutated KRAS induced YB-1 signaling in colorectal cancer cells and improves radiosensitivity by blocking repair of radiation-induced DNA double-strand breaks.Semantic proximity Read ↗

Pixantrone confers radiosensitization in KRAS mutated cancer cells by suppression of radiation-induced prosurvival pathways.Semantic proximity Read ↗

CPT1A Mediates Radiation Sensitivity in Colorectal CancerSemantic proximity Read ↗

Targeting K-Ras-mediated DNA damage response in radiation oncology: Current status, challenges and future perspectivesSemantic proximity Read ↗

Radiosensitization of Glioblastoma by the K-ras Inhibitor RMC-6236Semantic proximity Read ↗

Oncogenic KRAS confers chemoresistance by upregulating NRF2.Semantic proximity Read ↗

Targeting components of the alternative NHEJ pathway sensitizes KRAS mutant leukemic cells to chemotherapy.Semantic proximity Read ↗

PREX2 contributes to radiation resistance by inhibiting radiotherapy-induced tumor immunogenicity via cGAS/STING/IFNs pathway in colorectal cancerSemantic proximity Read ↗

Metformin Radiosensitizes p53-Deficient Colorectal Cancer Cells through Induction of G2/M Arrest and Inhibition of DNA Repair ProteinsSemantic proximity Read ↗

Enhanced dependency of KRAS-mutant colorectal cancer cells on RAD51-dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae.Semantic proximity Read ↗

EGFR-mediated chromatin condensation protects KRAS-mutant cancer cells against ionizing radiation.Semantic proximity Read ↗

Baseline MAPK signaling activity confers intrinsic radioresistance to KRAS-mutant colorectal carcinoma cells by rapid upregulation of heterogeneous nuclear ribonucleoprotein K (hnRNP K).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.