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Article

Pathogenic Mutation in VPS35 Impairs Its Protection against MPP<sup>+</sup> Cytotoxicity

1 Jan 2013

Abstract excerpt

Parkinson's disease primarily results from progressive degeneration of dopaminergic neurons in the substantia nigra. Both neuronal toxicants and genetic factors are suggested to be involved in the disease pathogenesis. The mitochondrial toxicant 1-methyl-4-phenylpyridinium (MPP(+)) shows a highly selective toxicity to dopaminergic neurons. Recent studies indicate that mutation in the vacuolar protein sorting 35...

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PMID: 23411763
DOI: 10.7150/ijbs.5617

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