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Article

Paternal age effects on sperm FOXK1 and KCNA7 methylation and transmission into the next generation.

Human molecular genetics - 15 Nov 2016

Atsem Stefanie, Reichenbach Juliane, Potabattula Ramya, Dittrich Marcus, Nava Caroline, Depienne Christel, Böhm Lena, Rost Simone, Hahn Thomas, Schorsch Martin, Haaf Thomas, El Hajj Nady

Abstract excerpt

Children of older fathers carry an increased risk for developing autism and other disorders. To elucidate the underlying mechanisms, we investigated the correlation of sperm DNA methylation with paternal age and its impact on the epigenome of the offspring. Methylation levels of nine candidate genes and LINE-1 repeats were quantified by bisulfite pyrosequencing in sperm DNA of 162 donors and 191 cord blood...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Forkhead Transcription Factors

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Share to Promoter Regions, Genetic

Share to Shaker Superfamily of Potassium Channels

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Source

Open in PubMed Open full text

Identifiers

PMID: 28171595
DOI: 10.1093/hmg/ddw328
PMCID: PMC5418740

Genes

FOXK1
KCNA7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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