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Paternal-age-related de novo mutations and risk for five disorders

10 Jul 2019

Abstract excerpt

There are established associations between advanced paternal age and offspring risk for psychiatric and developmental disorders. These are commonly attributed to genetic mutations, especially de novo single nucleotide variants (dnSNVs), that accumulate with increasing paternal age. However, the actual magnitude of risk from such mutations in the male germline is unknown. Quantifying this risk would clarify the...

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PMID: 31292440
DOI: 10.1038/s41467-019-11039-6

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