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Article

Epigenetic Signatures in Family Clusters: Links Between Male Fertility and Autism Risk.

Urology - 1 Jul 2026

Dehghanbanadaki Hojat, Chen Justin, Thorogood Samantha L, Ramsay Joemy M, Hotaling James M

Abstract excerpt

Autism spectrum disorder (ASD) prevalence has increased globally. Emerging evidence implicates paternal genetic and epigenetic factors, particularly sperm DNA methylation alterations, in shaping offspring neurodevelopmental risk. Advanced paternal age is associated with increased de novo mutations and epigenetic changes in germ cells. Recent studies have explored distinct sperm methylation signatures in fathers...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42031263
DOI: 10.1016/j.urology.2026.04.032

Genes

RBFOX1
SALL3
WWOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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