Article
Increased paternal age and the influence on burden of genomic copy number variation in the general population.
Human genetics - 1 Apr 2013
Buizer-Voskamp Jacobine E, Blauw Hylke M, Boks Marco P M, van Eijk Kristel R, Veldink Jan H, Hennekam Eric A M, Vorstman Jacob A S, Mulder Flip, Tiemeier Henning, Uitterlinden André G, Kiemeney Lambertus A, van den Berg Leonard H, Kahn René S, Sabatti Chiara, Ophoff Roel A
Abstract excerpt
Genomic copy number variations (CNVs) and increased parental age are both associated with the risk to develop a variety of clinical neuropsychiatric disorders such as autism, schizophrenia and bipolar disorder. At the same time, it has been shown that the rate of transmitted de novo single nucleo...
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