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Article

Age-specific DNA methylation alterations in sperm at imprint control regions may contribute to the risk of autism spectrum disorder in offspring.

Aging - 29 Dec 2025

Casella Eugenia, Depovere Jana, Delger Chantal, Butynets Mariia, Antczak Philipp, Price Thomas, Jirtle Randy L, Murphy Susan K, Hoyo Cathrine, Soubry Adelheid

Abstract excerpt

Research findings suggest that advanced paternal age is associated with an increased risk of autism spectrum disorder (ASD) in children. The biological process behind this father-to-child inheritance of a disease may be driven by sperm epigenetic marks. This has been suggested earlier, but the identification of epigenomic regions responsible for these age-related responses have not been further elaborated. To...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41474634
DOI: 10.18632/aging.206348
PMCID: PMC13147729

Genes

B4GALNT4
CDH24
DLGAP2
FBRSL1
GNAS
GRB10
KCNQ1
MAGEL2
OTX1
PLAGL1
PRDM16
PTPRN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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