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Article

Age-associated sperm DNA methylation alterations: possible implications in offspring disease susceptibility.

PLoS genetics - 1 Jul 2014

Jenkins Timothy G, Aston Kenneth I, Pflueger Christian, Cairns Bradley R, Carrell Douglas T

Abstract excerpt

Recent evidence demonstrates a role for paternal aging on offspring disease susceptibility. It is well established that various neuropsychiatric disorders (schizophrenia, autism, etc.), trinucleotide expansion associated diseases (myotonic dystrophy, Huntington's, etc.) and even some forms of cancer have increased incidence in the offspring of older fathers. Despite strong epidemiological evidence that these...

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Identifiers

PMID: 25010591
DOI: 10.1371/journal.pgen.1004458
PMCID: PMC4091790

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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