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Article

Advanced paternal age effects in neurodevelopmental disorders—review of potential underlying mechanisms

31 Jan 2017

Abstract excerpt

Multiple epidemiological studies suggest a relationship between advanced paternal age (APA) at conception and adverse neurodevelopmental outcomes in offspring, particularly with regard to increased risk for autism and schizophrenia. Conclusive evidence about how age-related changes in paternal gametes, or age-independent behavioral traits affect neural development is still lacking. Recent evidence suggests that...

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PMID: 28140401
DOI: 10.1038/tp.2016.294

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