CYP2D6*11 and challenges in clinical genotyping of the highly polymorphic CYP2D6 gene.

doi:10.2217/pgs.12.56

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Article

CYP2D6*11 and challenges in clinical genotyping of the highly polymorphic CYP2D6 gene.

Pharmacogenomics - 1 Jun 2012

Skierka Jennifer M, Walker Denise L, Peterson Sandra E, O'Kane Dennis J, Black John Logan

Abstract excerpt

CYP2D6 is genotyped clinically for prediction of response to tamoxifen, psychotropic drugs and other medications. Phenotype prediction is dependent upon accurate genotyping. The CYP Allele Nomenclature Committee maintains the allelic nomenclature for CYP2D6; however, in some cases, the list of polymorphisms associated with a given allele is incomplete. Clinical laboratories and in vitro diagnostic manufacturers...

Topics

Alleles
Cytochrome P-450 CYP2D6
Gene Deletion
Gene Duplication
Genotype
Humans
Polymorphism, Single Nucleotide

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Open in PubMed

Identifiers

PMID: 22676198
DOI: 10.2217/pgs.12.56

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