Article
Allele Drop Out Conferred by a Frequent CYP2D6 Genetic Variation For Commonly Used CYP2D6*3 Genotyping Assays.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2017
Scantamburlo Giada, Tziolia Konstantina, Zopf Michaela, Bernardinelli Emanuele, Soyal Selma M, Civello Davide Antonio, Vanoni Simone, Dossena Silvia, Patsch Wolfgang, Patrinos George P, Paulmichl Markus, Nofziger Charity
Abstract excerpt
BACKGROUND/AIM: Accurate genotyping of CYP2D6 is challenging due to its inherent genetic variation, copy number variation (duplications and deletions) and hybrid formation with highly homologous pseudogenes. Because a relatively high percentage (∼25%) of clinically prescribed drugs are substrates for this enzyme, accurate determination of its genotype for phenotype prediction is essential. METHODS: A cohort of...
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