Article
The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function.
Scientific reports - 7 Feb 2017
He Shan, Cao Yu, Xie Ping, Dong Guanglong, Zhang Lingqiang
Abstract excerpt
Nedd8 is a ubiquitin-like protein that controls vital biological events through conjugation to target proteins. We previously identified the HECT-type ubiquitin ligase Smurf1 which controls diverse cellular processes is activated by Nedd8 through covalent neddylation. However, the effect of non-covalent binding to Nedd8 remains unknown. In this study, we demonstrate that both Smurf1 and its homologue Smurf2 carry...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.