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Article

Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain.

Cell - 24 Aug 2007

Wiesner Silke, Ogunjimi Abiodun A, Wang Hong-Rui, Rotin Daniela, Sicheri Frank, Wrana Jeffrey L, Forman-Kay Julie D

Abstract excerpt

Ubiquitination of proteins is an abundant modification that controls numerous cellular processes. Many Ubiquitin (Ub) protein ligases (E3s) target both their substrates and themselves for degradation. However, the mechanisms regulating their catalytic activity are largely unknown. The C2-WW-HECT-domain E3 Smurf2 downregulates transforming growth factor-beta (TGF-beta) signaling by targeting itself, the adaptor...

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Identifiers

PMID: 17719543
DOI: 10.1016/j.cell.2007.06.050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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