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Article

Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity.

Nature structural & molecular biology - 1 Feb 2007

Sakata Eri, Yamaguchi Yoshiki, Miyauchi Yasuhiro, Iwai Kazuhiro, Chiba Tomoki, Saeki Yasushi, Matsuda Noriyuki, Tanaka Keiji, Kato Koichi

Abstract excerpt

Although cullin-1 neddylation is crucial for the activation of SCF ubiquitin E3 ligases, the underlying mechanisms for NEDD8-mediated activation of SCF remain unclear. Here we demonstrate by NMR and mutational studies that NEDD8 binds the ubiquitin E2 (UBC4), but not NEDD8 E2 (UBC12). Our data im...

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Source

Identifiers

PMID: 17206147
DOI: 10.1038/nsmb1191

Genes

NEDD8
RBX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17206147-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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