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Article

Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin negatively regulates Wnt/β-catenin signaling.

Molecular and cellular biology - 1 Oct 2013

Fei Cong, Li Zhenfei, Li Chen, Chen Yuelei, Chen Zhangcheng, He Xiaoli, Mao Li, Wang Xin, Zeng Rong, Li Lin

Abstract excerpt

Ubiquitination plays important and diverse roles in modulating protein functions. As a C2-WW-HECT-type ubiquitin ligase, Smad ubiquitination regulatory factor 1 (Smurf1) commonly serves to regulate ubiquitin-dependent protein degradation in a number of signaling pathways. Here, we report a novel function of Smurf1 in regulating Wnt/β-catenin signaling through targeting axin for nonproteolytic ubiquitination. Our...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23959799
DOI: 10.1128/MCB.00418-13
PMCID: PMC3811687

Genes

LRP5
LRP6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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