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Article

Smad2-dependent protease nexin-1 overexpression differentiates chronic aneurysms from acute dissections of human ascending aorta.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2013

Gomez Delphine, Kessler Ketty, Borges Luciano F, Richard Benjamin, Touat Ziad, Ollivier Véronique, Mansilla Silvana, Bouton Marie-Christine, Alkoder Soleyman, Nataf Patrick, Jandrot-Perrus Martine, Jondeau Guillaume, Vranckx Roger, Michel Jean-Baptiste

Abstract excerpt

OBJECTIVE: Tissue activation of proteolysis is involved in acute intramural rupture (dissections, acute ascending aortic dissection) and in progressive dilation (aneurysms, thoracic aneurysm of the ascending aorta) of human ascending aorta. The translational aim of this study was to characterize the regulation of antiproteolytic serpin expression in normal, aneurysmal, and dissecting aorta. APPROACH AND RESULTS:...

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Source

Identifiers

PMID: 23814118
DOI: 10.1161/ATVBAHA.113.301327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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