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Article

Hexarelin attenuates abdominal aortic aneurysm formation by inhibiting SMC phenotype switch and inflammasome activation.

Microvascular research - 1 Mar 2022

Jiang Bo, Wang Mo, Li Xue, Ren Pengwei, Li Guangxin, Wang Yuqi, Wang Lei, Li Xuan, Yang Dong, Qin Lingfeng, Xin Shijie

Abstract excerpt

Hexarelin, a synthetic growth hormone-releasing peptide, is shown to be protective in cardiovascular diseases such as myocardial infraction and atherosclerosis. However, the functional role of hexarelin in abdominal aortic aneurysm (AAA) remains undefined. The present study determined the effect of hexarelin administration (200 μg/kg twice per day) in a mouse model of elastase-induced abdominal aortic aneurysm....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34856183
DOI: 10.1016/j.mvr.2021.104280

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