Article
Risk of Early-Onset Depression Associated With Polygenic Liability, Parental Psychiatric History, and Socioeconomic Status.
JAMA psychiatry - 1 Apr 2021
Agerbo Esben, Trabjerg Betina B, Børglum Anders D, Schork Andrew J, Vilhjálmsson Bjarni J, Pedersen Carsten B, Hakulinen Christian, Albiñana Clara, Hougaard David M, Grove Jakob, McGrath John J, Bybjerg-Grauholm Jonas, Mors Ole, Plana-Ripoll Oleguer, Werge Thomas, Wray Naomi R, Mortensen Preben Bo, Musliner Katherine L
Abstract excerpt
Importance: Combining information on polygenic risk scores (PRSs) with other known risk factors could potentially improve the identification of risk of depression in the general population. However, to our knowledge, no study has estimated the association of PRS with the absolute risk of depression, and few have examined combinations of the PRS and other important risk factors, including parental history of...
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