Article
Dissecting the genetic heterogeneity of depression through age at onset.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Oct 2012
Power Robert A, Keers Robert, Ng Mandy Y, Butler Amy W, Uher Rudolf, Cohen-Woods Sarah, Ising Marcus, Craddock Nick, Owen Michael J, Korszun Ania, Jones Lisa, Jones Ian, Gill Michael, Rice John P, Hauser Joanna, Henigsberg Neven, Maier Wolfgang, Zobel Astrid, Mors Ole, Placentino Anna S, Rietschel Marcella, Souery Daniel, Kozel Dejan, Preisig Martin, Lucae Susanne, Binder Elisabeth B, Aitchison Katherine J, Tozzi Federica, Muglia Pierandrea, Breen Gerome, Craig Ian W, Farmer Anne E, Müller-Myhsok Bertram, McGuffin Peter, Lewis Cathryn M
Abstract excerpt
Genome-wide studies in major depression have identified few replicated associations, potentially due to heterogeneity within the disorder. Several studies have suggested that age at onset (AAO) can distinguish sub-types of depression with specific heritable components. This paper investigates the role of AAO in the genetic susceptibility for depression using genome-wide association data on 2,746 cases and 1,594...
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