Article
Pathway-analysis of published genome-wide association studies of lung cancer: A potential role for the CYP4F3 locus.
Molecular carcinogenesis - 1 Jun 2017
Yin Jieyun, Liu Hongliang, Liu Zhensheng, Owzar Kouros, Han Younghun, Su Li, Wei Yongyue, Hung Rayjean J, Brhane Yonathan, McLaughlin John, Brennan Paul, Bickeboeller Heike, Rosenberger Albert, Houlston Richard S, Caporaso Neil, Landi Maria Teresa, Heinrich Joachim, Risch Angela, Christiani David C, Amos Christopher I, Wei Qingyi
Abstract excerpt
The fatty acids (FAs) metabolism is suggested to play a pivotal role in the development of lung cancer, and we explored that by conducting a pathway-based analysis. We performed a meta-analysis of published datasets of six genome wide association studies (GWASs) from the Transdisciplinary Research in Cancer of the Lung (TRICL) consortium, which included 12 160 cases with lung cancer and 16 838 cancer-free...
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