Article
Informed genome-wide association analysis with family history as a secondary phenotype identifies novel loci of lung cancer.
Genetic epidemiology - 1 Mar 2015
Poirier Julia G, Brennan Paul, McKay James D, Spitz Margaret R, Bickeböller Heike, Risch Angela, Liu Geoffrey, Le Marchand Loic, Tworoger Shelley, McLaughlin John, Rosenberger Albert, Heinrich Joachim, Brüske Irene, Muley Thomas, Henderson Brian E, Wilkens Lynne R, Zong Xuchen, Li Yafang, Hao Ke, Timens Wim, Bossé Yohan, Sin Don D, Obeidat Ma'en, Amos Christopher I, Hung Rayjean J
Abstract excerpt
Lung cancer is the leading cause of cancer death worldwide. Although several genetic variants associated with lung cancer have been identified in the past, stringent selection criteria of genome-wide association studies (GWAS) can lead to missed variants. The objective of this study was to uncover missed variants by using the known association between lung cancer and first-degree family history of lung cancer to...
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