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Article

Metabolome-wide association study identified the association between a circulating polyunsaturated fatty acids variant rs174548 and lung cancer.

Carcinogenesis - 26 Oct 2017

Wang Cheng, Qin Na, Zhu Meng, Chen Minjian, Xie Kaipeng, Cheng Yang, Dai Juncheng, Liu Jia, Xia Yankai, Ma Hongxia, Jin Guangfu, Amos Christopher I, Hu Zhibin, Lin Dongxin, Shen Hongbing

Abstract excerpt

Quantitative trait loci (QTLs) are widely used as instruments to infer causal risk factors of diseases based on the idea of mendelian randomization. Plasma metabolites can serve as risk factors of cancer, and the heritability of many circulating metabolites was high. We conducted a metabolome-wide association study (MWAS) to systematically investigate the effects of genetic variants on metabolites and lung cancer...

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Identifiers

PMID: 28968813
DOI: 10.1093/carcin/bgx084
PMCID: PMC6410942

Genes

FADS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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