Article
Pathway analysis for genome-wide association study of lung cancer in Han Chinese population.
PloS one - 1 Jan 2013
Zhang Ruyang, Zhao Yang, Chu Minjie, Wu Chen, Jin Guangfu, Dai Juncheng, Wang Cheng, Hu Lingmin, Gou Jianwei, Qian Chen, Bai Jianling, Wu Tangchun, Hu Zhibin, Lin Dongxin, Shen Hongbing, Chen Feng
Abstract excerpt
Genome-wide association studies (GWAS) have identified a number of genetic variants associated with lung cancer risk. However, these loci explain only a small fraction of lung cancer hereditability and other variants with weak effect may be lost in the GWAS approach due to the stringent significance level after multiple comparison correction. In this study, in order to identify important pathways involving the...
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