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Article

Discovery of new candidate genes for rheumatoid arthritis through integration of genetic association data with expression pathway analysis.

Arthritis research & therapy - 2 Feb 2017

Shchetynsky Klementy, Diaz-Gallo Lina-Marcella, Folkersen Lasse, Hensvold Aase Haj, Catrina Anca Irinel, Berg Louise, Klareskog Lars, Padyukov Leonid

Abstract excerpt

BACKGROUND: Here we integrate verified signals from previous genetic association studies with gene expression and pathway analysis for discovery of new candidate genes and signaling networks, relevant for rheumatoid arthritis (RA). METHOD: RNA-sequencing-(RNA-seq)-based expression analysis of 377 genes from previously verified RA-associated loci was performed in blood cells from 5 newly diagnosed, non-treated...

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Source

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Identifiers

PMID: 28148290
DOI: 10.1186/s13075-017-1220-5
PMCID: PMC5288892

Genes

ERBB2
THOP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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