Article
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
Nature - 20 Feb 2014
Okada Yukinori, Wu Di, Trynka Gosia, Raj Towfique, Terao Chikashi, Ikari Katsunori, Kochi Yuta, Ohmura Koichiro, Suzuki Akari, Yoshida Shinji, Graham Robert R, Manoharan Arun, Ortmann Ward, Bhangale Tushar, Denny Joshua C, Carroll Robert J, Eyler Anne E, Greenberg Jeffrey D, Kremer Joel M, Pappas Dimitrios A, Jiang Lei, Yin Jian, Ye Lingying, Su Ding-Feng, Yang Jian, Xie Gang, Keystone Ed, Westra Harm-Jan, Esko Tõnu, Metspalu Andres, Zhou Xuezhong, Gupta Namrata, Mirel Daniel, Stahl Eli A, Diogo Dorothée, Cui Jing, Liao Katherine, Guo Michael H, Myouzen Keiko, Kawaguchi Takahisa, Coenen Marieke J H, van Riel Piet L C M, van de Laar Mart A F J, Guchelaar Henk-Jan, Huizinga Tom W J, Dieudé Philippe, Mariette Xavier, Bridges S Louis, Zhernakova Alexandra, Toes Rene E M, Tak Paul P, Miceli-Richard Corinne, Bang So-Young, Lee Hye-Soon, Martin Javier, Gonzalez-Gay Miguel A, Rodriguez-Rodriguez Luis, Rantapää-Dahlqvist Solbritt, Arlestig Lisbeth, Choi Hyon K, Kamatani Yoichiro, Galan Pilar, Lathrop Mark, Eyre Steve, Bowes John, Barton Anne, de Vries Niek, Moreland Larry W, Criswell Lindsey A, Karlson Elizabeth W, Taniguchi Atsuo, Yamada Ryo, Kubo Michiaki, Liu Jun S, Bae Sang-Cheol, Worthington Jane, Padyukov Leonid, Klareskog Lars, Gregersen Peter K, Raychaudhuri Soumya, Stranger Barbara E, De Jager Philip L, Franke Lude, Visscher Peter M, Brown Matthew A, Yamanaka Hisashi, Mimori Tsuneyo, Takahashi Atsushi, Xu Huji, Behrens Timothy W, Siminovitch Katherine A, Momohara Shigeki, Matsuda Fumihiko, Yamamoto Kazuhiko, Plenge Robert M
Abstract excerpt
A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated variants with diverse genomic and biological data sets to provide insight into disease pathogenesis and guide drug discovery for complex traits such as rheumatoid arthritis (RA). Here we performed a genome-wide association study meta-analysis in a total of >100,000 subjects of European and Asian ancestries...
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