Article
Synovial transcriptome-wide association study implicates novel genes underlying rheumatoid arthritis risk.
Rheumatology (Oxford, England) - 1 May 2025
Hu Shou-Ye, Jiang Feng, Song Hui-Miao, Wang Ya-Kang, Tian Wen, Wu Hao, Yao Shi, He Chang-Yi, Gao Hui-Wu, Yang Tie-Lin, Yang Zhi, Guo Yan
Abstract excerpt
OBJECTIVES: This study aimed to address the lack of gene expression regulation data in synovial tissues and to identify genes associated with rheumatoid arthritis (RA) in the synovium, a primary target tissue for RA. METHODS: Gene expression prediction models were built for synovial tissue using matched genotype and gene expression data from 202 subjects. Using this model, we conducted a transcriptome-wide...
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