Article

Integrative Multiomics Network Analysis of Genetic Risk Factors to Infer Biomarkers and Therapeutic Targets for Rheumatoid Arthritis

2024-01-05

Abstract excerpt

<title>Abstract</title> <p><bold>Purpose</bold>: Understanding the interplay between multiomics genetic risk factors in rheumatoid arthritis (RA) is key to developing effective treatments. Although network genetic-medicine approaches have identified key regulatory nodes of RA, there has been limited analysis of the molecular interactions between its risk actors. <bold>Methods</bold>: To identify the significant p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9e6dd84a-c90b-5ee3-8bdf-78eddd51a1df
DOI: 10.21203/rs.3.rs-3607429/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative Multiomics Network Analysis of Genetic Risk Factors to Infer Biomarkers and Therapeutic Targets for Rheumatoid ArthritisDOI 10.21203/rs.3.rs-3607429/v1Read

A genomics-based systems approach towards drug repositioning for rheumatoid arthritis.Semantic proximity Read

A systematic method for mapping multiple loci: an application to construct a genetic network for rheumatoid arthritis.Semantic proximity Read

Novel loci and multi-omics risk models for rheumatoid arthritis through a million-participant genome-wide association meta-analysisSemantic proximity Read

The Identification of Novel Therapeutic Biomarkers in Rheumatoid Arthritis: A Combined Bioinformatics and Integrated Multi-Omics ApproachSemantic proximity Read

Genetics of rheumatoid arthritis contributes to biology and drug discovery.Semantic proximity Read

A large-scale multi-omics polygenic risk score analysis identified candidate risk locus associated with rheumatoid arthritis.Semantic proximity Read

A network-based model for drug repurposing in Rheumatoid ArthritisSemantic proximity Read

Integrative Analysis of Genetic, Proteomic, and Transcriptomic Data Reveals Novel Therapeutic Targets for Rheumatoid ArthritisSemantic proximity Read

Pathway-based association analysis of two genome-wide screening data identifies rheumatoid arthritis-related pathways.Semantic proximity Read

Knowledge-based analysis of genetic associations of rheumatoid arthritis to inform studies searching for pleiotropic genes: a literature review and network analysis.Semantic proximity Read

Integrative analysis of genome-wide association studies and gene expression analysis identifies pathways associated with rheumatoid arthritis.Semantic proximity Read

Super-omics and PCAS reveal tumor-like molecular landscape of rheumatoid arthritisSemantic proximity Read