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Marker Genes Change of Synovial Fibroblasts in Rheumatoid Arthritis Patients

1 Jan 2021

Abstract excerpt

BACKGROUND: Rheumatoid arthritis (RA) is a chronic condition that manifests as inflammation of synovial joints, leading to joint destruction and deformity. METHODS: We identified single-cell RNA-seq data of synovial fibroblasts from RA and osteoarthritis (OA) patients in GSE109449 dataset. RA- and OA-specific cellular subpopulations were identified, and enrichment analysis was performed. Further, key genes for RA...

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PMID: 34195267
DOI: 10.1155/2021/5544264

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