Article

Cyclin-G-associated kinase GAK/dAux regulates autophagy initiation via ULK1/Atg1 in glia

2021-08-19

Abstract excerpt

Autophagy is a major means for the elimination of protein inclusions in neurons in neurodegenerative diseases such as Parkinson’s disease (PD). Yet, the mechanism of autophagy in the other brain cell type, glia, is less well characterized and remains largely unknown. Here we present evidence that the PD risk factor Cyclin G-associated kinase (GAK)/dAuxilin (dAux) is a new component in glial autophagy. GAK/dAux dir...

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Literature Corpus work: faf4daa5-e0db-53e8-8b84-fa18a4d5b2ed
DOI: 10.1101/2021.08.16.456579

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