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Article

Cholangiocarcinoma Heterogeneity Revealed by Multigene Mutational Profiling: Clinical and Prognostic Relevance in Surgically Resected Patients.

Annals of surgical oncology - 1 May 2016

Ruzzenente Andrea, Fassan Matteo, Conci Simone, Simbolo Michele, Lawlor Rita T, Pedrazzani Corrado, Capelli Paola, D'Onofrio Mirko, Iacono Calogero, Scarpa Aldo, Guglielmi Alfredo

Abstract excerpt

BACKGROUND: Cholangiocarcinoma can be classified in intrahepatic cholangiocarcinoma (ICC) and perihilar cholangiocarcinoma (PCC). Moreover, PCC includes two different forms: extrahepatic (EH) PCC, which arises from the perihilar EH large ducts, and intrahepatic (IH) PCC, in which a significant liver mass invades the perihilar bile ducts. In this study, we investigated the molecular profile and molecular...

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Share to Bile Duct Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26717940
DOI: 10.1245/s10434-015-5046-6

Genes

IDH1
KRAS
ALK
BAP1
NRAS
PBRM1
STK11
TGFBR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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