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Article

IDH Mutation Subgroup Status Associates with Intratumor Heterogeneity and the Tumor Microenvironment in Intrahepatic Cholangiocarcinoma.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Sept 2021

Xiang Xiao, Liu Ziyang, Zhang Chong, Li Zhao, Gao Jie, Zhang Changkun, Cao Qi, Cheng Jinghui, Liu Hengkang, Chen Dingbao, Cheng Qian, Zhang Ning, Xue Ruidong, Bai Fan, Zhu Jiye

Abstract excerpt

Intrahepatic cholangiocarcinoma (ICC) is highly heterogeneous. Here, the authors perform exome sequencing and bulk RNA sequencing on 73 tumor regions from 14 ICC patients to portray the multi-faceted intratumor heterogeneity (ITH) landscape of ICC. The authors show that ITH is highly concordant across genomic, transcriptomic, and immune levels. Comparison of these data to 8 published datasets reveals...

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Identifiers

PMID: 34250753
DOI: 10.1002/advs.202101230
PMCID: PMC8425914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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