Article
Genomic profiling of intrahepatic cholangiocarcinoma: refining prognosis and identifying therapeutic targets.
Annals of surgical oncology - 1 Nov 2014
Zhu Andrew X, Borger Darrell R, Kim Yuhree, Cosgrove David, Ejaz Aslam, Alexandrescu Sorin, Groeschl Ryan Thomas, Deshpande Vikram, Lindberg James M, Ferrone Cristina, Sempoux Christine, Yau Thomas, Poon Ronnie, Popescu Irinel, Bauer Todd W, Gamblin T Clark, Gigot Jean Francois, Anders Robert A, Pawlik Timothy M
Abstract excerpt
BACKGROUND: The molecular alterations that drive tumorigenesis in intrahepatic cholangiocarcinoma (ICC) remain poorly defined. We sought to determine the incidence and prognostic significance of mutations associated with ICC among patients undergoing surgical resection. METHODS: Multiplexed mutational profiling was performed using nucleic acids that were extracted from 200 resected ICC tumor specimens from 7...
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