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The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-Ribosylhydrolase

9 Nov 2020

Abstract excerpt

SARS-CoV-2 has recently emerged into the human population and has led to a worldwide pandemic of COVID-19 that has caused more than 1.2 million deaths worldwide. With no currently approved treatments, novel therapeutic strategies are desperately needed. All coronaviruses encode a highly conserved macrodomain (Mac1) that binds to and removes ADP-ribose adducts from proteins in a dynamic posttranslational process...

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PMID: 33158944
DOI: 10.1128/jvi.01969-20

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The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-RibosylhydrolasePMID 33158944Read ↗

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