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Article

High-Throughput Activity Assay for Screening Inhibitors of the SARS-CoV-2 Mac1 Macrodomain

14 Dec 2021

Abstract excerpt

Macrodomains are a class of conserved ADP-ribosylhydrolases expressed by viruses of pandemic concern, including coronaviruses and alphaviruses. Viral macrodomains are critical for replication and virus-induced pathogenesis; therefore, these enzymes are a promising target for antiviral therapy. However, no potent or selective viral macrodomain inhibitors currently exist, in part due to the lack of a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34904435
DOI: 10.1021/acschembio.1c00721

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